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Title: N170 asymmetry as an index of inferior occipital dysfunction in patients with symptomatic occipital lobe epilepsy
Authors: Lopes, Ricardo
Cabral, Pedro
Canas, Nuno
Breia, Paula
Foreid, John P.
Calado, Eulália
Silva, Rita
Leal, Alberto
Keywords: Epilepsy
Occipital lobe
Issue Date: Jan-2011
Publisher: Elsevier
Abstract: Objective: Localizing epileptic foci in posterior brain epilepsy remains a difficult exercise in surgery for epilepsy evaluation. Neither clinical manifestations, neurological, EEG nor neuropsychological evaluations provide strong information about the area of onset, and fast spread of paroxysms often produces mixed features of occipital, temporal and parietal symptoms. We investigated the usefulness of the N170 event-related potential to map epileptic activity in these patients. Methods: A group of seven patients with symptomatic posterior cortex epilepsy were submitted to a high-resolution EEG (78 electrodes), with recordings of interictal spikes and face-evoked N170. Generators of spikes and N170 were localized by source analysis. Range of normal N170 asymmetry was determined in 30 healthy volunteers. Results: In 3 out of 7 patients the N170 inter-hemispheric asymmetry was outside control values. Those were the patients whose spike sources were nearest (within 3 cm) to the fusiform gyrus, while foci further away did not affect the N170 ratio. Conclusions: N170 event-related potential provides useful information about focal cortical dysfunction produced by epileptic foci located in the close neighborhood of the fusiform gyrus, but are unaffected by foci further away. Significance: The N170 evoked by faces can improve the epileptic foci localization in posterior brain epilepsy
Description: WOS:000285406600005 (Nº de Acesso Web of Science)
“Prémio Científico ISCTE-IUL 2012”
Peer reviewed: Sim
ISSN: 1388-2457
Publisher version: The definitive version is available at:
Appears in Collections:CIS-RI - Artigos em revistas científicas internacionais com arbitragem científica

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