Skip navigation
Logo
User training | Reference and search service

Library catalog

Retrievo
EDS
b-on
More
resources
Content aggregators
Please use this identifier to cite or link to this item:

acessibilidade

http://hdl.handle.net/10071/6803
acessibilidade
Title: White matter changes and diabetes predict cognitive decline in the elderly: the LADIS study
Authors: Verdelho, Ana
Madureira, S.
Moleiro, Carla
Ferro, J. M.
Santos, C. O.
Erkinjuntti, T.
Pantoni, L.
Fazekas, F.
Visser, M.
Waldemar, G.
Wallin, A.
Hennerici, M.
Inzitari, D.
LADIS Study
Issue Date: 2010
Publisher: Lippincott Williams & Wilkins
Abstract: Objective: We aimed to study if age-related white matter changes (WMC) and vascular risk factors were predictors of cognitive decline in elderly subjects with WMC living independently. Methods: The Leukoaraiosis and Disability prospective multinational European study (LADIS) evaluates the impact of WMC on the transition of independent elderly subjects into disability. Independent elderly were enrolled due to the presence of WMC. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and a neuropsychological battery. Additionally, dementia, subtypes of dementia, and cognitive decline without dementia were classified according to usual clinical criteria. MRI was performed at entry and at the end of the study. Results: A total of 639 subjects were included (74.1 ± 5 years, 55% women, 9.6 ± 3.8 years of schooling). At end of follow-up, 90 patients had dementia and 147 had cognitive impairment no dementia. Using Cox regression analysis, WMC severity independently predicted cognitive decline (dementia and not dementia), independently of age, education, and medial temporal atrophy (MTA). Diabetes at baseline was the only vascular risk factor that independently predicted cognitive decline during follow-up, controlling for age, education, WMC severity, and temporal atrophy. Considering subtypes of dementia, Alzheimer disease (AD) was predicted only by MTA, while vascular dementia was predicted by previous stroke, WMC severity, and MTA. Conclusion: WMC severity and diabetes are independent predictors of cognitive decline in an initially nondisabled elderly population. Vascular dementia is predicted by previous stroke and WMC, while AD is predicted only by MTA.
Description: WOS:000280103900012 (Nº de Acesso Web of Science)
“Prémio Científico ISCTE-IUL 2011”
Peer reviewed: Sim
URI: http://hdl.handle.net/10071/6803
ISSN: 0028-3878
Publisher version: The definitive version is available at: http://dx.doi.org/10.1212/WNL.0b013e3181e7ca05
Appears in Collections:CIS-RI - Artigos em revistas científicas internacionais com arbitragem científica

Files in This Item:
acessibilidade
File Description SizeFormat 
Verdelho 2010 Neurology.pdf6.29 MBAdobe PDFView/Open    Request a copy


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Currículo DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.