Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10071/29208
Autoria: | Cosme, G. Arriaga, P. Rosa, P. J. Mehta, M. A. Prata, D. |
Data: | 2023 |
Título próprio: | Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study |
Título da revista: | Journal of Psychopharmacology |
Volume: | 37 |
Número: | 6 |
Paginação: | 566 - 576 |
Referência bibliográfica: | Cosme, G., Arriaga, P., Rosa, P. J., Mehta, M. A., & Prata, D. (2023). Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study. Journal of Psychopharmacology, 37(6), 566-576. https://dx.doi.org/10.1177/02698811231158233 |
ISSN: | 0269-8811 |
DOI (Digital Object Identifier): | 10.1177/02698811231158233 |
Palavras-chave: | Electrocardiography Neuropeptide Pharmacodynamics Pupil unrest Resting state |
Resumo: | Background: Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the autonomic nervous system (ANS) activity; however, IN-OT’s effect on the temporal profile of ANS activity at rest is yet to be described. Aims: We aimed to describe the temporal profile of IN-OT at six 10-min time windows from 15- to 100-min post-administration in 20 male participants at rest while continuously recording their pupillary in an eyes-open condition and cardiac activity in eyes-open and eyes-closed conditions. Methods: We used a double-blind, placebo-controlled, within-subjects design study where we extracted two proxies of parasympathetic nervous system (PNS) activity: high-frequency heart rate variability (HF-HRV) and pupillary unrest index (PUI); and a proxy of sympathetic nervous system activity: sample entropy of the pupillary unrest. Results: In the eyes-open condition, we found an effect of IN-OT on the proxies of PNS activity: decreased PUI in the three-time windows post-administration spanning 65–100 min, and as an exploratory finding, an increased HF-HRV in the 80–85 min time window. Conclusions: We suggest there is a role of OT in PNS regulation that may be consistent with OT’s currently theorized role in the facilitation of alertness and approach behavior. |
Arbitragem científica: | yes |
Acesso: | Acesso Aberto |
Aparece nas coleções: | CIS-RI - Artigos em revistas científicas internacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Tamanho | Formato | |
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article_95290.pdf | 1,17 MB | Adobe PDF | Ver/Abrir |
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