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Author(s): Tavares, V.
Fernandes, L. F.
Antunes, M.
Ferreira, H. A.
Prata, D.
Date: 2022
Title: Sex differences in functional connectivity between resting state brain networks in autism spectrum disorder
Volume: N/A
ISSN: 0162-3257
DOI (Digital Object Identifier): 10.1007/s10803-021-05191-6
Keywords: Functional connectivity
Resting-state networks
Autism spectrum disorder
Independent component analysis
Functional magnetic resonance imaging
Abstract: Functional brain connectivity (FBC) has previously been examined in autism spectrum disorder (ASD) between-resting-state networks (RSNs) using a highly sensitive and reproducible hypothesis-free approach. However, results have been inconsistent and sex differences have only recently been taken into consideration using this approach. We estimated main effects of diagnosis and sex and a diagnosis by sex interaction on between-RSNs FBC in 83 ASD (40 females/43 males) and 85 typically developing controls (TC; 43 females/42 males). We found increased connectivity between the default mode (DM) and (a) the executive control networks in ASD (vs. TC); (b) the cerebellum networks in males (vs. females); and (c) female-specific altered connectivity involving visual, language and basal ganglia (BG) networks in ASD—in suggestive compatibility with ASD cognitive and neuroscientific theories.
Peerreviewed: yes
Access type: Open Access
Appears in Collections:CIS-RI - Artigos em revistas científicas internacionais com arbitragem científica

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