Utilize este identificador para referenciar este registo: http://hdl.handle.net/10071/10930
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dc.contributor.authorPereira, S.-
dc.contributor.authorLavado, N.-
dc.contributor.authorNogueira, L.-
dc.contributor.authorGuevara Lopez, M. A.-
dc.contributor.authorAbreu, J. M.-
dc.contributor.authorSilva, H. C.-
dc.date.accessioned2016-02-24T15:23:53Z-
dc.date.available2016-02-24T15:23:53Z-
dc.date.issued2013-
dc.identifier.issn1354-523Xpor
dc.identifier.urihttps://ciencia.iscte-iul.pt/public/pub/id/22704-
dc.identifier.urihttp://hdl.handle.net/10071/10930-
dc.descriptionWOS:000342667100005 (Nº de Acesso Web of Science)-
dc.description.abstractObjectiveOrthodontic-induced external apical root resorption (EARR) is a complex phenotype determined by poorly defined mechanical and patient intrinsic factors. The aim of this work was to construct a multifactorial integrative model, including clinical and genetic susceptibility factors, to analyze the risk of developing this common orthodontic complication. Materials and MethodsThis retrospective study included 195 orthodontic patients. Using a multiple-linear regression model, where the dependent variable was the maximum% of root resorption (%EARRmax) for each patient, we assessed the contribution of nine clinical variables and four polymorphisms of genes involved in bone and tooth root remodeling (rs1718119 from P2RX7, rs1143634 from IL1B, rs3102735 from TNFRSF11B, encoding OPG, and rs1805034 from TNFRSF11A, encoding RANK). ResultsClinical and genetic variables explained 30% of%EARRmax variability. The variables with the most significant unique contribution to the model were: gender (P<0.05), treatment duration (P<0.001), premolar extractions (P<0.01), Hyrax appliance (P<0.001) and GG genotype of rs1718119 from P2RX7 gene (P<0.01). Age, overjet, tongue thrust, skeletal class II and the other polymorphisms made minor contributions. ConclusionThis study highlights the P2RX7 gene as a possible factor of susceptibility to EARR. A more extensive genetic profile may improve this model.por
dc.language.isoengpor
dc.publisherWiley-Blackwellpor
dc.rightsembargoedAccesspor
dc.subjectApical root resorptionpor
dc.subjectGene polymorphismpor
dc.subjectOrthodonticspor
dc.subjectP2RX7 genepor
dc.titlePolymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorptionpor
dc.typearticleen_US
dc.pagination659-667por
dc.publicationstatusPublicadopor
dc.peerreviewedSimpor
dc.relation.publisherversionThe definitive version is available at: http://dx.doi.org/10.1111/odi.12185por
dc.journalOral Diseasespor
dc.distributionInternacionalpor
dc.volume20por
dc.number7por
degois.publication.firstPage659por
degois.publication.lastPage667por
degois.publication.issue7por
degois.publication.titleOral Diseasespor
dc.date.updated2016-02-24T15:21:56Z-
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