Geometric optimal control of the generalized Lotka–Volterra model of the intestinal microbiome

dc.contributor.authorBonnard, B.
dc.contributor.authorRouot, J.
dc.contributor.authorSilva, C. J.
dc.date.accessioned2024-03-26T12:23:07Z
dc.date.issued2024
dc.date.updated2024-03-26T12:21:20Z
dc.description.abstractWe introduce the theoretical framework from geometric optimal control for a control system modeled by the generalized Lotka–Volterra equation, motivated by restoring the gut microbiota infected by Clostridium difficile combining antibiotic treatment and fecal injection. We consider both permanent control and sampled-data control related to the medical protocols.eng
dc.description.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.citationBonnard, B., Rouot, J., & Silva, C. J. (2024). Geometric optimal control of the generalized Lotka–Volterra model of the intestinal microbiome. Optimal Control Applications and Methods, 45(2), 544-574. https://doi.org/10.1002/oca.3089
dc.identifier.doi10.1002/oca.3089
dc.identifier.issn0143-2087
dc.identifier.urihttp://hdl.handle.net/10071/31400
dc.language.isoeng
dc.number2
dc.pagination544 - 574
dc.peerreviewedyes
dc.publisherWiley
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04106%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F00564%2F2018%2FCP1559%2FCT0001/PT
dc.rightsopen access
dc.subjectBiomathematics and population dynamicseng
dc.subjectOptimal control in the permanent caseeng
dc.subjectSampled-data controleng
dc.subject.fosDomínio/Área Científica::Ciências Naturais::Matemáticaspor
dc.subject.fosDomínio/Área Científica::Ciências Naturais::Ciências da Computação e da Informaçãopor
dc.subject.fosDomínio/Área Científica::Engenharia e Tecnologia::Engenharia Civilpor
dc.subject.fosDomínio/Área Científica::Engenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informáticapor
dc.subject.fosDomínio/Área Científica::Ciências Sociais::Economia e Gestãopor
dc.titleGeometric optimal control of the generalized Lotka–Volterra model of the intestinal microbiomeeng
dc.typearticle
dc.volume45
dspace.entity.typePublicationen
iscte.alternateIdentifiers.scopus2-s2.0-85184442574
iscte.alternateIdentifiers.wosWOS:WOS:001157199500001
iscte.identifier.cienciahttps://ciencia.iscte-iul.pt/id/ci-pub-102813
iscte.journalOptimal Control Applications and Methods

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